منابع مشابه
C4nr03962a 500..510 ++
Tumor associated macrophages (TAMs) can modify the tumor microenvironment to create a pro-tumor niche. Manipulation of the TAM phenotype is a novel, potential therapeutic approach to engage anticancer immunity. siRNA is a molecular tool for knockdown of specific mRNAs that is tunable in both strength and duration. The use of siRNA to reprogram TAMs to adopt an immunogenic, anti-tumor phenotype ...
متن کاملDev115980 510..521
UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated DNA during replication and is essential for maintaining DNA methylation. uhrf1 mutant zebrafish have global DNA hypomethylation and display embryonic defects, including a small liver, and theydie as larvae.Wemake the surprising finding that, despite their reduced organ size, uhrf1mutants express h...
متن کاملDmd062596 510..522
Clopidogrel is a prodrug that needs to be converted to its active metabolite (clopi-H4) in two sequential cytochrome P450 (P450)dependent steps. In the present study, a dynamic physiologically based pharmacokinetic (PBPK) model was developed in Simcyp for clopidogrel and clopi-H4 using a specific sequential metabolite module in four populations with phenotypically different CYP2C19 activity (po...
متن کاملJ409_25d 507..510
The ocean's interior is Earth's largest biome. Recently, cultivationindependent ribosomal RNA gene surveys have indicated a potential importance for archaea in the subsurface ocean. But quantitative data on the abundance of speci®c microbial groups in the deep sea are lacking. Here we report a year-long study of the abundance of two speci®c archaeal groups (pelagic euryarchaeota and pelagic cre...
متن کاملPns1200075 502..510
The mammalian target of rapamycin complex 1 (mTORC1) pathway is known to couple different environmental cues to the regulation of several energy-demanding functions within the cell, spanning from protein translation to mitochondrial activity. As a result, at the organism level, mTORC1 activity affects energy balance and general metabolic homoeostasis by modulating both the activity of neuronal ...
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ژورنال
عنوان ژورنال: IUCrData
سال: 2019
ISSN: 2414-3146
DOI: 10.1107/s2414314619011799